Help to Overcome Problems Effectively. This means you have the drugs and then a rest to allow your body to recover. This completes your first cycle of XELOX. Sometimes, looking back, I wonder if I had just pushed myself a little more, I may not have suffered as much as I did. Good luck with the rest of your treatment. Getting to the park and walkling around got some exercise happening and just put me in a great mental state. They include: We have more information about side effects and tips on how to cope with them. Capecitabine and oxaliplatin drug monographs, Cancer Care Ontario. Progression-free survival and response rates did not differ significantly among the regimens. Oxaliplatin forms crosslinks that inhibit DNA replication and transcription, resulting in cell death in actively dividing cells. This treatment may cause headaches. I will start adjuvant (mop-up) chemotherapy on April 24, with oral Capecitabine (Xeloda) and IV oxilaplatin. Your healthcare team will tell you what moisturiserto use. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae). You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme. Tell your doctor or nurse if you have ulcers. Accessing the HOPE course through Macmillan Wellsprings story. Try to take gentle exercise, such as walking. Your doctor will tell you the amount (dose) of capecitabine you need to take. This treatment may cause a sore mouth and throat. Your donations make it happen. And would sleep close to 40 out of 48 hours. I am pretty new on this forum. I kind of wonder if this will go away soon. ObjectiveTo compare the efficacy of adjuvant chemotherapy with six or eight cycles of S-1 plus oxaliplatin (SOX) or Capecitabine plus oxaliplatin (XELOX) after D2 resection of GC.Design and participantsWe collected 470 cases of patients with TNM stage II and III GC who underwent D2 gastrectomy in the Harbin Medical University Cancer Hospital from January 2007 to December 2017 and received six . administration of oxaliplatin can be given. They are named after the initials of the drugs used for treatment. Some foods may taste different or have no taste. The skin may also begin to peel. Both went away after a few days. Were here to provide physical, financial and emotional support. Most people get it along with Xeloda. You have oxaliplatin and capecitabine chemotherapy as cycles of treatment. Treatment options are often the same for both stage 4 and recurrent rectal cancer. You may also have tingling, numbness, pain and dryness. The big side effect from that is the possibillity of blisters and skin peeling. Coping with cancer can be difficult. This treatment may also cause blurry vision. I am an otherwise healthy and active 58 year old man. You might also feel feverish and your eyes may be more sensitive to light. Your doctor or nurse may talk to you about having vaccinations. This issue has come up here in the past and hopefully others can chime in. For colorectal cancer: If cisplatin is substituted by oxaliplatin and 5-FU by . Oxaliplatin and capecitabineside effects, tinnitus, has anyone else suffered with this as I'm thinking of cutting out the Oxaliplatin for the last 2 sessions to save my hearing or am I being over causious, many thanks. Patients who were treated with both oxaliplatin and capecitabine had a higher risk of experiencing toxic side effects. They may suggest that you dissolve the capecitabine tablets in water. You may need a drip to give you extra platelets. But it has subsided. If rectal cancer comes back (recurs), it usually comes back in a distant site such as the . This is called hand-foot syndrome or palmar plantar syndrome. Whetheryou have a full or an empty stomach can affect how much of a drug gets into your bloodstream. Maybe you'll be one who doesn't react badly. XELOX (or CAPOX) is used to treat bowel cancer. Hi: I found out I had a tumor in my upper colon on February 7, 2017. The National Comprehensive Cancer Network (NCCN) has released new guidelines for ampullary adenocarcinoma, a disease accounting for just 0.2% of all gastrointestinal malignancies. I think I would definitely run this past your oncologist as some of the oxaliplatin side effects can get worse even after stopping and its not something that you would want to risk having on a permanent basis. If the number of platelets is low, you may bruise or bleed easily. A lot of it may just be luck or makeup, things not in our control, but mindset and determination are also a big part of all of this. Contact the hospital straight away if you feel any discomfort or stinging when you pass urine, or if you notice any blood in it. If it is something where you can say screw it and deal with it later, that could be easier. But the team was on the road One of the things that is most important it try not to worry or dwell on this s--t that has been handed to you. I stayed out of bed. This is because the drugs could be passed to the baby through breast milk. Best of luck to you, I hope your side effects are minor and tolerable. The drugs are: Your doctor will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment. Call freephone 9 to 5 Monday to Friday or email us. Let your nurse know straight away if your drip site is causing you pain. Less commonly you might also bleed from other areas of the body for other reasons. They can give you advice and prescribe creams to improve any symptoms you have. sometime have programs to help with the cost. And women might be able to store eggs or ovarian tissue. You may get sore and red palms of hands and soles of feet. Authors Tabraiz A Mohammed 1 , Trevor Dennie, Kyle D Holen. This usually goes back to normal when your treatment finishes. You take capecitabine tablets from the evening of day 1 to the morning of day 15. Help to Overcome Problems Effectively. your temperature goes below 36C (96.8F). Capecitabine and lapatinib were given orally at escalating doses, starting at capecitabine 1500 mg/m(2)/day on days 1-14 and lapatinib 1000 mg daily on days 1-21. Make sure to hang out and ask questions during all of this, you got this man. I wrote my. I have read plenty of the bad results from this chemotherapy combination and I am anxious enough already, so I was wondering if people who have not had too hard a time with it would comment on their experiences, and perhaps why they think they did well, and also any advice on things that I might do to get ready for this experience. Your nurse can give you more advice. This could be a sign of infection or more rarely lung problems such as asthma, a blood clot in the lung, a collapsed lung (pneumothorax), or changes to the lung tissue, making it less flexible. Repeat every 21 days for 4 cycles for low-risk stage III colon cancer (T1-3/N1). Irinotecan & Capecitabine (14 day regimen) (I-Cap) Protocol V1.1. It helps by slowing the growth of blood vessels to provide food for the tumors. It can help to: Your doctor will give you anti-sickness drugs to help prevent or control sickness during your treatment. Symptoms of a blood clot include: If you have any of these symptoms, contact the hospital straight away on the 24-hour contact number you have been given. When I first started getting it they gave it to me over 3 hours. Other rare skin changes include ulcers, raised areas of skin that may be itchy, being sensitive to sunlight and previously treated areas of skin with radiation can become irritated and inflamed. Always tell other doctors, nurses, pharmacists or dentists that youre having this treatment. Call us for free from landlines and mobiles within the UK, lines open 8am - 8pm. Even if going out to get a cup of coffee for a bit. Skinproblemsincludea skin rash which might be red and itchy. God bless us all troopers!! This includes vitamins, herbal supplements and over the counter remedies. These cells fight infection. This is to make sure they work as well as possible for you. I hope it's the same for you! Contact your advice line as soon as possible if: Early treatment can help manage side effects better. Constipation is easier to sort out if you treat it early. Arm C received 3 cycles of neoadjuvant SOX and 5 cycles of adjuvant SOX . It is almost always temporary, and your hair will usually grow back after treatment finishes. Contact the hospital straight away on the 24-hour contact number you have been given if: It is important to follow any specific advice your cancer treatment team gives you. Chemotherapy forum requires membership for participation - click to join, Break in chemotherapy because of side effects. It is also known as colorectal cancer. . The oxilaplatin was unpleasant with the neuropathy side effects but it's different for everyone and having to do it now that spring is here will help. I'm a contractor and to keep working was a necessity, but I believe it kept my focus off how every little thing felt, and helped my body pump it through, if that makes any sense. And some days when I forced myself to get past intertia. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. This treatment can reduce the number of platelets in your blood. Welcome. You can talk to your cancer doctor about your risk of having DPD deficiency before you start treatment. avoid alcohol, tobacco, and foods that irritate your mouth and throat. Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm. Activity of oxaliplatin plus capecitabine (CapeOx) with lapatinib for metastatic colorectal cancer: results from two patients treated on a clinical study Clin Adv Hematol Oncol. You might want to hurry and get a few pairs of those stretchy knit gloves that are one size fits all. Contact your advice line or doctor straight away if you have any of these symptoms, eye problems such as watery eyes, inflammation of the conjunctiva (conjunctivitis) or vision changes such as blurred or double vision, high blood pressure, much more rarely you may get a low blood pressure, kidney changes you will have regular blood tests to check for this, problems with passing urine such as burning or stinging when going, passing blood and changes to how often you go. Depending on your needs, you may have between 4 and 8 cycles. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. It is also important to empty your bladder regularly and to try to pass urine as soon as you feel the need to go. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer? This side effect can be frightening, but it should only be temporary. After your treatment is over, most side effects start to improve. The capecitabine and oxaliplatin with RT group received identical postoperative RT to that in the capecitabine with RT group combined with capecitabine (1300 mg/m 2) on days 1 to 14 and 22 to 35 and a 2-hour infusion of oxaliplatin (60 mg/m 2) on weeks 1, 2, 4, and 5. My dose is three tablets twice a . On day 1 you have oxaliplatin as an infusion. If you have a stoma, it will be more active than usual. Background: Oxaliplatin, combined with capecitabine (CAPOX) or infused 5-fluorouracil (FOLFOX), is standard of care in the adjuvant treatment of colorectal cancer (CRC). I wish you luck as you start your chemo jouney. I did lose body hair, and realized one day I I had no eye lashes. There, that sounded less commanding. Well, I can't tell you what to do, so let me re-word that. I was on both plus Avastin for 6 treatments (later on just Xeloda and Avastin). The week I was on chemo was the time when I dropped a bit of weight, was fortunate not nauseous, but not hungry. Rarely, oxaliplatin can cause a spasm in the throat area around the voicebox (larynx). There are some rare side effects that are not listed. Let your nurse know straight away if it's affecting your breathing and swallowing. The risk of this happening is very low (less than 1 in 100 or 1%). You may have: Tell your doctor if you have any unexplained bruising or bleeding. I had to quit my job due to my chemo therapy. You might have treatment through a long plastic tubethat goesinto a large vein in your chest. The Macmillan Support Line offers confidential support to people living with cancer and their loved ones. Glad your comfortable with your decision. You are advised not to breastfeedwhile having this treatment, or for some time after treatment finishes. Rarely, oxaliplatin can affect the nervous system. Donate today to help people with cancer live life as fully as they can. Repeat every 21 days for 8 cycles for high-risk stage III colon cancer (any T4 and . We also include some less common side effects. Your nurse will give you telephone numbers for the hospital. court over 3 years ago. Talk to your doctor if you are worried about this. If you have headaches, tell your doctor. Sometimes people who have had the live shingles vaccine can get a shingles type rash. You may have nosebleeds or bleeding gums after brushing your teeth. You might be breathlessand lookpale due to a drop in red blood cells. Its a horrible condition . Your hospital team may give you anti-diarrhoea drugs to take at home. They check your levels of blood cells and other substances in the blood. Also operating in Northern Ireland. If you have any of these symptoms, you should stop taking the capecitabine tablets until you have spoken to your doctor. Your cancer doctor or GP can tell you more about live and inactivated vaccinations. Your nurse can talk to you about ways to cope with hair loss. You might have other symptoms depending on where the infection is. Other people should avoid direct contact with the chemotherapy drugs. You have oxaliplatin as a drip into your bloodstream over 2 hours. You might have one or more of them. This symptom may be worse in cold temperatures. I had it surgically removed on March 22. Talk to your doctor or nurse about effective contraception before starting treatment. If I'm tired I take a nap, but I try to be as active as I can. Bowel cancer means cancer that starts in the colon (large bowel) or back passage (rectum). You may feel bloated or have indigestion or wind. Take the drugs exactly as your nurse or pharmacist tells you. Before starting treatment with capecitabine you have a blood test to check levels of an enzyme called dihydropyrimidine dehydrogenase (DPD). Capecitabine is taken as tablets. Always take your tablets exactly as explained. You might have two different strengths of tablets to make up the correct dose. sometimes severe nausea and sometimes not. They can check the cause and give you medicine to help. Some cancer drugs can affect whether you can get pregnantor make someone pregnant. Macmillan Cancer Support 2020 Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Very rarely, this can cause heart failure or a heart attack. But some can be permanent. Babies have the live rotavirus vaccine. your side effects arent getting any better, blood clots that can be life threatening; signs are pain, redness and swelling where the clot is. Donate today to help people with cancer live life as fully as they can. I'm not sure if this is related to the Capecitabine or the Oxaliplatin that I get via infusion every 3 weeks. Cancer and some cancer treatments can increase the risk of a blood clot. This treatment might harm a baby developing in the womb. Diarrhoea means passing more stools (poo) than is usual for you, or having watery or loose stools. Results: Ten patients received treatment per study protocol. There may be a middle ground that just might help . If you need medical treatment for any reason other than cancer, always tell the doctors and nurses you are having cancer treatment. Capecitabine works best if it's broken down in the stomach with food. LOL. They may give the next doses of oxaliplatin over 4 to 6 hours to reduce the chance of throat spasms. Capecitabine has the potential to replace 5-FU/LV as the optimal combination partner for oxaliplatin at a higher cost. The difference in my mum was amazing and just gave her some quality of life again . If you have an intolerance to lactose, contact your doctor before taking this medicine. That's a very annoying side effect. Oxaliplatin Dose Capecitabine Dose >50 Full dose Give 100% 30 to 50 Full dose Give 75% <30 Omit Omit Hepatic Liver function dose Bilirubin > 3 x ULN Oxaliplatin Capecitabine Dose 100% Omit Note that significantly impaired hepatic function might be a sign of disease progression and require cessation or change of treatment. But for some people they may never go away. You may get pain or discomfort in your tummy (abdomen). The two big ones were neuropathy and the cold sensitivity. Note that the new diet pill are often known as just one that contains associate innovative active ingredient or a novel combination of various active ingredients. We cannot list every side effect for this treatment. This might happen during treatment, or in the first few days after treatment. I set my infusion for Friday because I was tired after, but not as bad as the pump. So pleased to hear its slow growing and wish you every success with the treatment . Use of this online service is subject to the disclaimer and the terms and conditions. Worth having a chat . 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle for a maximum of 8 cycles. Were here to provide physical, financial and emotional support. Always tell your cancer doctor about any drugs you are taking or planning to take, such as: Tell other doctors, pharmacists or dentists who prescribe or give you medicines that you are having this cancer treatment. The timing worked out well for me in that about 7 sessions in I started getting REAL tried about two days after disconnect. I'd come home from chemo with my fingers tingling, but not really painful. Side effects while treatment is being given. The tube stays in place throughout the course of treatment. Your doctor or nurse can give you more information. At that time I was only working M-W (not related to chemo). I am in generally good health, no medicines, conditions etc, other than this cancer thing. So I went out as much as possible. Keep them safe and out of sight and reach of children. I hope that you will hear from some of our members' experiences of these chemo tablets. These are both inactivated vaccinations that can help reduce the risk of infection. The combination of capecitabine and oxaliplatin, with or without bevacizumab, a monoclonal antibody . This is to check that your blood cells are at a safe level to have chemotherapy. I truly can relate with your feelings along with the experience of the financial issue. Materials and methods: A retrospective review of all patients with advanced colorectal cancer treated with oxaliplatin 130 mg/m2 on day 1 and capecitabine 2 g/m2 daily in two divided doses days 1-14 every 3 weeks, outside of a clinical trial at the Royal Marsden Hospital. The glass and spoon should be washed and kept separate from your other crockery and cooking utensils. Mother (66F, colon CA IIIB) is starting her 4th round of XELOX ( capecitabine +oxaliplatin) and has 4 more to go. Cancer drugs can interact with some other medicines and herbal products. The cold sensitivity is pretty bad for me. It can cause damage. They can prescribe a laxative. We know that it is common to struggle with your mental health when you have cancer or care for someone with cancer. Your doctor will advise you not to get pregnant or make someone pregnant while having this treatment. They will slow or stop your drip for a while andgive you medicine to help relieve your symptoms. It helps to keep your mouth and teeth clean, drink plenty of fluids and avoid acidic foods such as lemons. Although I mentioned it to the nurse who did my infusions I never mentioned it to the oncologist. The oxy caused this weird cold sensitivity and "first bite" syndrome - temporarily feeling like there were glass shard in your throat - but very temporary. Your doctor may give you anti diarrhoea medicine to take home with you after treatment. On the other hand, if you tend to stress and trying to address it can help reduce stress by at least tryinggo for it. You usually take the tablets twice a day, about 12 hours apart. You should take them within 30 minutes of finishing a meal. This is who we mean when we mention doctor, nurse or pharmacist in this information. 1-21 Capecitabine 2625mg/m BD PO All patients must have documented DPYD status and capecitabine doses adjusted accordingly prior to commencing treatment as per local practice. Our Cancer Information Nurse Specialists are dedicated cancer nurses available to talk to on our Macmillan Cancer Support Line. Three out of eleven lymph nodes were positive. It is important not to become pregnant or father a child while you're having treatment and for 6 months afterwards. Goals of therapy: Capecitabine + oxaliplatin can be given to shrink tumors and decrease symptoms of colon cancer. Outline. I also have been left with painful feet which I did mention but not until after all my chemo had finished! Thank you all for your comments. a short thin tube the nurse puts into a vein in your arm or hand (, a fine tube that goes under the skin of your chest and into a vein close by (, a fine tube that is put into a vein in your arm and goes up into a vein in your chest (. Some cancer treatments can cause severe side effects. 2011 Jun;9(6):492-500. Some days I didn't make it off of the couch, and some days I didn't get out of my night clothes, but I did get out of bed. These blood cells help the blood to clot when we cut ourselves. One former member used to drink cold water while being infused with the oxy and it prevented a lot of the cold issues. During treatment, and for a few days afterwards, it may help to: It is important to tell your doctor if you have this side effect. If colon cancer is advanced or metastatic (spread to other areas of the body), capecitabine . Many facilities will have programs with finanical assistance, like MSK can set up payment plans and the rest to make it easier. Affiliation 1 . I had chemo on Monday, took the next 2 days off and then worked for the next 2 weeks with no problem. I liked Gold Bond Aloe, but everyone has their favorite. I usually feel a bit off (mostly low energy) for a week - week and a half, then I feel good for a week and a half - two weeks. Physicians . Try different foods to find out what tastes best to you. You have a new cannula each time you have treatment. FOLFIRNOX can be used in different ways. You have oxaliplatin into your bloodstream (intravenously). It is a treatment for bowel cancer (colorectal cancer). Registered office: 89 Albert Embankment, London SE1 7UQ. What's going on near you? FOLFIRINOX. I had a touch of each possible side effect, but limited. This is serious and could be life threatening, a blood disorder where your red blood cells get destroyed faster than they can be made (haemolytic anaemia), high levels of a type of fat in your blood, panic attacks this can make you feel as though your heart is pounding, sweating, feeling weak and dizzy and having trouble breathing, problems with your balance and coordination of your movements, the feeling of the room around you is spinning or moving (vertigo), flu-like symptoms such as fever, chills and muscle aches, imbalance of substances in your blood (metabolic acidosis) it can cause confusion, tiredness, shortness of breath and headaches, other vaccines, but they might not give you as much protection as usual, the coronavirus (COVID-19) vaccine - talk to your doctor or pharmacist about the best time to have it in relation to your cancer treatment. XELOX is usually given every 21 days. VAT no: 668265007. About Cancer generously supported by Dangoor Education since 2010. I was also lucky with good blood work. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniquescan allhelp. Whatever cancer throws your way, were right there with you. The virus is in the babys poo for about 2 weeks and could make you ill if your immunity is low. Based on the gene mutation profile, the patient received the bevacizumab-oxaliplatin regime and then the bevacizumab-capecitabine as maintenance treatment. It is important to use contraception during your treatment and for a while after treatment finishes. I was also stage three when I was diagnose over three years ago. The drugs may harm a developing baby. Just started FOLFOX on April 14/17. The oncologist wasn't convinced the AF was caused by chemo so when I had lung mets surgically removed in 2016 he prescribedcapecitabine as a mop- up treatment. Not the same chemo but I had severe pains in my joints all over my body also in my legs and feet. How often do you have oxaliplatin and capecitabine? On day of hiccups, one day bad bowel movements. your temperature goes over 37.5C (99.5F), you suddenly feel unwell, even with a normal temperature. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . For instance, some people might notice their poo is quite dark or they might pass fresh blood. You will not know without a test if you have DPD deficiency, as there are no symptoms.