(The Environmental Protection Agency is responsible for approving external flea and tick products.) The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). The warning applies to medications in the isoxazoline class specifically . If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. Simparica TRIO (6.0 mg/0.12 mg/25. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. Im trying to find out if this is safe for her. Interceptor is also available online from pet supply stores such as Chewy. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. Where can I get them tested for MDR1 resistance. Hi Debbie! If your Collie doesnt play like that, you should be fine. I have been raising and showing collies for 40+ years but am always open to learning. Dec 26, 2017. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. They said Frontline Plus doesnt really work anymore like it used too. Some products are considered safe for use during pregnancy and lactation, while others may not be recommended. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) Hope this helps! Thank you, and hello to Nola and Otis! We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. It sounds similar to a couple other natural oil products Ive tried. Thank you for the useful information which is a little easier (clearer) to understand than most. I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Im just looking for advice as to tick prevention medication. Get new post updates in monthly email newsletters. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). The safe use of SIMPARICA has not been evaluated in breeding, pregnant, or lactating dogs. Safe in breeding, pregnant and lactating dogs. Thank you for such a great article! Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Sugar is a great name for a Collie as they really are such sweethearts. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. for, I think its brown ticks. The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. And use same collar for a few months. I have never even heard of the latter and do not believe they exist in Canada. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Have you had any issues with Seresto? I was unaware of MDR1 Mutation drug reactions at the time. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. Do you know what the ingredients are in the medicated shampoo? What can trigger a seizure in a dog? Im happy to hear it and so glad it helped! WSU is the leader inidentifyingdrugs that may be dangerousfor dogs with the MDR1 mutationand can identifyalternative medications and doses. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! We do eat it! Hi Vicki, No adverse effects were observed. We love her. Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. However, it does claim to kill fleas on contact. Thats what I plan to use in future, when my oldest dog reaches that point. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Wow! Simparica is for use only in dogs 6 months of age and older. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. I hate to use anything, but also tired of keeping my dogs in a bubble. SIMPARICA was administered in a well-controlled US field study, which included a total of 479 dogs (315 dogs treated with SIMPARICA and 164 dogs treated with active control once monthly for three treatments). However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Hi, Thank you for this helpful article. I like Frank so much that I had to give him his own story. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Consumed by free choice or with food 91.9% of the time See the Simparica Trio difference Compare the labels of other products with Simparica Trio * by killing deer ticks Heartgard has been out long enough that there are cheaper knockoffs available. ? I just took her off Sentinel Flavor Tabs. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. I read that you you used this combination with success. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. Hi Emily Thank you! I gave a mini aussie and a minnie aussie/border collie mix. When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. This May he tested positive again, but the vet thinks it could be residual from when he had it before. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Second, Id like to ask a question if you dont mind. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine.