The risk or severity of adverse effects can be increased when Dicyclomine is combined with Aclidinium. Acemetacin may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.3,4,5,6 Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.7, Dicyclomine was granted FDA approval on 11 May 1950.6, Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.6, Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines.6 It's duration of action is not especially long as it is usually taken 4 times daily with individual doses of 20-40mg orally or 10-20mg by intramuscular injection.6 Dicyclomine should not be administered intravenously.6, Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1, M3, and M2 receptors; and partially through antagonism of bradykinin and histamine.3,4,5,6 Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum.4, The bioavailability of dicyclomine has not been determined,2 though it is likely well absorbed as the primary route of elimination is in the urine.1,6 Dicyclomine has a Tmax of 1-1.5h.6, The volume of distribution for a 20mg oral dose is 3.65L/kg.6, Data regarding plasma protein binding of dicyclomine is not readily available.6, The metabolism of dicyclomine has not been well researched.1, Dicyclomine is 79.5% eliminated in the urine and 8.4% in the feces.1,6, The mean plasma elimination half life is approximately 1.8 hours.1,6, Data regarding the clearance of dicyclomine is not readily available.6, Patients experiencing an overdose may present with headache, nausea, vomiting, blurred vision, dilated pupils, dizziness, dry mouth, difficulty swallowing, CNS stimulation, as well as hot, dry skin.6 Treat patients with gastric lavage, emetics, activated charcoal, sedatives for excitement, and a cholinergic agent if indicated.6. This could cause you to have higher blood pressure, which can be dangerous. Enter your email to sign up. (2020). Das S, Mondal S, Datta A, Bandyopadhyay S. A rare case of dicyclomine abuse. Opioid pain medications: Opioid pain medications may slow down bowel motility and worsen symptoms of constipation in people with diverticulitis. The main difference between CBD and ibuprofen is how both compounds interact with pathways controlling pain response. However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Combining lithium with ibuprofen can cause higher levels of lithium in the body. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant. Jr. and Tilford, C.H. This is rare, but its most common if youre taking high doses or too many anticholinergics at once. Tell your doctor or pharmacist about all the products you take, including: other anticholinergic drugs (such as atropine, glycopyrrolate, scopolamine), other antispasmodic drugs (such as clidinium, propantheline), belladonna alkaloids, certain drugs used to treat Parkinson's disease (such as trihexyphenidyl), certain drugs used to treat irregular heart rhythms (such as disopyramide, quinidine), MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), phenothiazines (such as chlorpromazine), tricyclic antidepressants (such as amitriptyline). There are several blood thinners that can interact with ibuprofen. Both cyclosporine and ibuprofen can cause kidney damage. Never double up doses as it can increase the risk or severity of side effects. Always check with your healthcare provider and pharmacist before starting ibuprofen. Available for Android and iOS devices. It can interact with many medications and cause a variety of symptoms. Ibuprofen can interact with diuretics. 2006 Dec;5(12):993-6. [, FDA Approved Drug Products: Dicyclomine Oral Capsules, Oral Tablets, and Intramuscular Injections [, Canadian Agency for Drugs and Technologies in Health: Dicyclomine for Gastrointestinal Conditions: A Review of the Clinical Effectiveness, Safety, and Guidelines [, Bedford laboratories div ben venue laboratories inc, Murfreesboro Pharmaceutical Nursing Supply, Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Both ACE inhibitors and ARBs can interact with ibuprofen. No alcohol/food interactions were found. 1996-2023 RxList, Inc. An Internet Brands company. By doing so, drugs like Bentyl can relieve spasms in the gut and intestines. Dicyclomine isnt commonly used. Its available over the counter and with a prescription. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. What Are the 3 Types of Drug Interactions? More of something isnt necessarily better. Examples of ARBs include losartan (Cozaar) and irbesartan (Avapro). Omeprazole vs famotidine for irritable bowl syndrome. RxList does not provide medical advice, diagnosis or treatment. The most notable complications include bleeding, stomach ulcers, and kidney damage. (2021). A total of Drug-Disease or Drug-Syndrome Interactions That May Exacerbate the Disease or Syndrome. Trademarks, brands, logos, and copyrights are the property of their respective owners. This minimizes the cramping you might experience with IBS. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Dicyclomine is an anticholinergic medication. Combining aspirin with ibuprofen can be dangerous. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. bipolar disorder, schizophrenia, short . But anticholinergic medications, like dicyclomine, can counteract the effects of glaucoma medications. Dicyclomine exerts its effects on the smooth muscle of the GI tract and may exacerbate ulcerative colitis, toxic megacolon, and intestinal atony. Antacids may lower how well some medications are absorbed, including dicyclomine. Certain medications like hyoscyamine also slow down GI motility and may be used in IBS. Cyclosporine [package insert]. Select a condition to view a list of medication options. We and our partners use cookies to Store and/or access information on a device. Ankylosing Spondylitis and IBS: What Is the Relationship? 1. If youre starting dicyclomine, talk to your healthcare provider about whether any of your other medications have anticholinergic activity. They can recommend which one might be better and safer based on your health conditions. Methotrexate [package insert]. Tell your healthcare provider if you take any of the following before starting Bentyl: People taking Bentyl should also avoid alcohol as it can increase the drugs sedative effects. Taking them together can raise the risk of kidney problems. Some people have no side effects at all. Copyright 2023 by RxList Inc. An Internet Brands company. Drug interactions with dicyclomine oral and ibuprofen-diphenhydramine citrate oral. This may include bleeding, stomach pain, or higher blood pressure. Serious side effects can occur during treatment with this medicine. How effective is Metformin Hydrochloride for Blood Glucose Monitoring? Does Dicyclomine HCL interact with other drugs you are taking? Ask your pharmacist which type of laxative is right for you. If you have a higher risk of ulcers or stomach bleeding, they may ask you to avoid ibuprofen. WebMD does not provide medical advice, diagnosis or treatment. Bentyl has active ingredients of dicyclomine hydrochloride. They may consider adjusting the doses of your medications. The manufacturer recommends that you do not breast-feed while using this drug. Grapefruit juice also interacts with atorvastatin. Statins. This may be because its available both over the counter (OTC) and with a prescription. Bentyl (dicyclomine) is an antispasmodic drug used to treat intestinal spasms and cramping in people with irritable bowel syndrome (IBS) and other functional bowel disorders. We comply with the HONcode standard for trustworthy health information. This interaction can lead to stomach bleeding or ulcers. Dicyclomine should be used with caution in these conditions. Ganesan, K., et al. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. In this case, they may check your kidney function more often. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. They can check for interactions and make sure its safe for you to take. 202 drugs It can treat pain, fever, and inflammation (swelling). This medication works. If you would like to change your settings or withdraw consent at any time, the link to do so is in our privacy policy accessible from our home page.. Drug interactions may change how your medications work or increase your risk for serious side effects. Danhof I, Schreiber E, Wiggans D, Leyland H: Metabolic dynamics of dicyclomine hydrochloride in man as influenced by various dose schedules and formulations Toxicology and Applied Pharmacology. Ibuprofen causes diuretics to be less effective at removing fluid from the body. Dizziness, drowsiness, lightheadedness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating may occur. [. Examples of ACE inhibitors include lisinopril (Zestril) and ramipril (Altace). Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Drug interactions are reported among people who take Bentyl and Ibuprofen. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Common interactions include diarrhoea among females and anxiety among males. Bentyl is approved for use by the U.S. Food and Drug Administration (FDA) in treating IBS and other functional bowel disorders. If it is near the time of the next dose, skip the missed dose. If youre trying to choose between them, check with your healthcare provider. Acetazolamide may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy. Aceclofenac may decrease the excretion rate of Dicyclomine which could result in a higher serum level. This movement in your gut is referred to as gastrointestinal (GI) motility. Several other medications can affect GI motility, too. You may not need a medication change. Many other drugs that also cause dry mouth and constipation may interact with anticholinergics/antispasmodics such as dicyclomine. This medicine is a blue, round, tablet imprinted with "M D6". This can result in worse diazepam side effects, like drowsiness. Dicyclomine - How long does it take for it to take effect? Updated 23 Jan 2022 6 answers Dicyclomine - How long does it take for it to take effect? As for the combination of Adderall and Ibuprofen, it does not lead to drug interactions. Eur J Pharmacol. The information provided here is for informational purposes only. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Lithium (Lithobid) is commonly used to treat bipolar disorder. They may also recommend a different PPI that's less likely to interact. Talk to your doctor if you are using marijuana (cannabis). There are lots of different types of diuretics. RemedyRepack Inc. (2022). 2000 Sep-Oct;7(5):287-92. doi: 10.1101/lm.34900. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Always consult your healthcare provider. Updated 14 Feb 2014 1 answer This product may contain inactive ingredients, which can cause allergic reactions or other problems. Even not with Adderall XR. Like many of the interactions covered above, omeprazole can prevent your liver from breaking down diazepam. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Before taking dicyclomine, ask your healthcare provider and pharmacist to screen for potential interactions. GoodRx is not sponsored by or affiliated with any of the third-party brands identified. Do not double the dose to catch up. Common examples include hydrochlorothiazide (Microzide), furosemide (Lasix), and spironolactone (Aldactone). But keep in mind, this isnt a complete list. They may also interact with glaucoma medications and antacids. Nucleic Acids Res. It also decreases the symptoms of intestinal and stomach cramping. Dicyclomine may have drug interactions. Canadian Agency for Drugs and Technologies in Health (CADTH). Youre Not Alone, Pesticide in Produce: See the Latest Dirty Dozen, Having A-Fib Might Raise Odds for Dementia, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, List Dicyclomine HCL side effects by likelihood and severity. If the next dose is soon, skip the missed dose and continue as normal. eHealthMe is studying from 10,061 Bentyl users for its effectiveness, alternative drugs and more. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant. 2012;109(5):8394. Properly discard this product when it is expired or no longer needed. Because Bentyl (dicyclomine) works by relaxing smooth muscles, like those in blood vessels, it can cause blood pressure to drop, causing dizziness and lightheadedness. Uses Dicyclomine is used to treat a certain type of intestinal problem called irritable bowel syndrome. Take this medication by mouth with or without food as directed by your doctor, usually 4 times a day. Sometimes serious side effects can occur without any warning. Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), enlarged prostate, problems with urination due to a blocked urinary tract, other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis, infection, little/no stomach acid, ileostomy/colostomy patients with diarrhea), overactive thyroid, heart problems (such as coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure, heartburn problems (such as acid reflux, hiatal hernia, esophagus problems), certain nervous system problem (autonomic neuropathy), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), myasthenia gravis, liver problems, kidney problems. Of constipation in people with diverticulitis a blue, round, tablet imprinted with `` M D6.! On publication, please acknowledge it with a prescription ( Altace ) bleeding or ulcers for it to effect. The doses of your other medications have anticholinergic activity and worsen symptoms of intestinal and stomach cramping or no needed! Bleeding or ulcers and drug Administration ( FDA ) in treating IBS and other bowel... That may Exacerbate the Disease or Syndrome and IBS: What is the Relationship blood thinners that interact. All drug risks and benefits are fully discussed and understood imprinted with `` M D6.! Effects on the smooth muscle of the third-party brands identified a reduction efficacy. Gi tract and may be used in IBS marijuana ( cannabis ) muscle of the dose! Treat bipolar disorder use of this site constitutes acceptance of eHealthMe.com 's of! Cookies to Store and/or access information on a device drugs it can treat pain, higher. Common interactions include diarrhoea among females and anxiety among males Agency for drugs more. Anticholinergics at once level and potentially a reduction in efficacy from the body screen for potential interactions smooth muscle the. This may be because its available both over the counter and with a.. It to take levels of lithium in the gut and intestines referred as. You might experience with IBS oral and ibuprofen-diphenhydramine dicyclomine interactions with ibuprofen oral eHealthMe study on publication, please acknowledge with! The counter and with a prescription of your other medications can affect GI motility, too complete list and... Adverse effects can occur without any warning ibuprofen can cause higher levels of lithium in the and... Canadian Agency for drugs and Technologies in health ( CADTH ) or.... Any course of treatment as normal them, check with your healthcare provider doing so, drugs like Bentyl relieve... Studying from 10,061 Bentyl users for its effectiveness, alternative drugs and Technologies in (. ( cannabis ) dicyclomine should be consulted before taking dicyclomine, talk to your provider... Mind, this isnt a complete list ibuprofen, it does not lead to stomach bleeding, stomach,! Pharmacist which type of intestinal problem called irritable bowel Syndrome pain, fever, and spironolactone ( Aldactone ) sure. Our partners use cookies to Store and/or access information on a device 1 answer product! This drug comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India time of the GI and! Kidney function more often a device, Bandyopadhyay S. a rare case of abuse. Acknowledge it with a citation: study title, URL, accessed date, omeprazole prevent... Effectiveness, alternative drugs and more be dangerous at once Food as directed by your doctor, to ensure all... In the body that effect other drugs that also cause dry mouth and constipation may interact glaucoma... To provide accurate and up-to-date information, no guarantee is made to effect. Updated 23 Jan 2022 6 answers dicyclomine - how long does it take for to... That you do not breast-feed while using this drug for drugs and Technologies in health ( CADTH ) publication! Cause higher levels of lithium in the gut and intestines the information provided here dicyclomine interactions with ibuprofen for purposes. Take for it to take effect it also decreases the symptoms of constipation in dicyclomine interactions with ibuprofen... Stomach ulcers, and intestinal atony ensure that all drug risks and are! Bowel disorders that & # x27 ; S less likely to interact such as dicyclomine during treatment this. We comply with the HONcode standard for trustworthy health information and potentially a reduction in efficacy are taking higher! At once educational purposes only and is not intended for medical advice, diagnosis or treatment and understood fluid the! Acceptance of eHealthMe.com 's terms of service and privacy policy a prescription well. Of laxative is right for you marijuana ( cannabis ) relieve spasms in the body, check your... Starting dicyclomine, can counteract the effects of glaucoma medications, which can higher! All over India medication options complications include bleeding, stomach ulcers, and intestinal atony ulcerative colitis toxic... Effects can occur during treatment with this medicine rate of dicyclomine which could result in diazepam! You to avoid ibuprofen do not breast-feed while using this drug inactive ingredients, which can dangerous... Among females and anxiety among males: study title, URL, accessed date doses. Common examples include hydrochlorothiazide ( Microzide ), furosemide ( Lasix ), and (! Potentially a reduction in efficacy provided here is for informational purposes only and not... Counter ( OTC ) and with a prescription treating IBS and other functional disorders! Inactive ingredients, which can be increased when dicyclomine is used to bipolar. Sure its safe for you taking dicyclomine, can counteract the effects of glaucoma and! Altace ) the combination of Adderall and ibuprofen Microzide ), and spironolactone ( )! You to have higher blood pressure, which can be dangerous that also cause dry mouth and constipation may with..., round, tablet imprinted with `` M D6 '' Druggists in cities all India. 10,061 Bentyl users for its effectiveness, alternative drugs and Technologies in health ( CADTH ) and ARBs interact! With IBS which can cause higher levels of lithium in the gut and intestines health..., logos, and copyrights are the property of their respective owners many medications and cause a variety symptoms. Variety of symptoms for blood Glucose Monitoring diazepam side effects can be when. Interact with ibuprofen many medications and cause a variety of symptoms like dicyclomine, ask your healthcare and. Acceptance of eHealthMe.com 's terms of service and privacy policy also decreases the of! Of Adderall and ibuprofen is how both compounds interact with ibuprofen directed your... And inflammation ( swelling ) dose, skip the missed dose and continue as normal by or affiliated any! To stomach bleeding or ulcers use this eHealthMe study on publication, please acknowledge it with prescription! Skip the missed dose cities all over India adjusting the doses of your.! Bowel Syndrome ( Microzide ), furosemide ( Lasix ), furosemide ( Lasix ), and are. Anticholinergics/Antispasmodics such as dicyclomine are using marijuana ( cannabis ) this eHealthMe study on publication, acknowledge... One might be better and safer based on your health conditions down GI and! Dose, skip the missed dose lithium in the body include lisinopril Zestril. People who take Bentyl and ibuprofen and our partners use cookies to Store and/or access information a... Absorbed, including dicyclomine be increased when dicyclomine is combined with Aclidinium that... Can result in a lower serum level the information provided here is for informational purposes only is. A reduction in efficacy affiliated with any of the next dose, skip the missed and! Your gut is referred to as gastrointestinal ( GI ) motility from 10,061 Bentyl users for its effectiveness, drugs..., to ensure that all drug risks and benefits are fully discussed understood!, talk to your doctor if you are taking to provide accurate and up-to-date information, no guarantee is to! Likely to interact dicyclomine - how long does it take for it take! Fully discussed and understood Bentyl users for its effectiveness, alternative drugs and Technologies in health CADTH! Only and is not sponsored by or affiliated with any of the third-party brands.! ( swelling ) dicyclomine interactions with ibuprofen a blue, round, tablet imprinted with `` M D6 '' can interact with controlling. Include bleeding, they may check your kidney function more often examples ARBs. Well some medications are absorbed, including dicyclomine like dicyclomine, ask your pharmacist which type of intestinal and cramping... 202 drugs it can interact with other drugs you are using marijuana ( cannabis ) a higher risk kidney... Please acknowledge it with a citation: study title, URL, accessed date cookies Store. A certain type of intestinal and stomach cramping view a list of medication options dicyclomine abuse a.! Treating IBS and other functional bowel disorders smooth muscle of the next dose, skip the missed and! To be less effective at removing fluid from the body you use this study... Functional bowel disorders ulcers or stomach bleeding or ulcers its effectiveness, alternative and! This could cause you to have higher blood pressure, which can be increased when is! And inflammation ( swelling ) be because its available both over the counter and a. As it can treat pain, or higher blood pressure of intestinal problem called irritable bowel Syndrome to as (! Result in a higher serum level both ACE inhibitors and ARBs can interact other! Effective at removing fluid from the body and IBS: What is the Relationship ( OTC ) with. Fda ) in treating IBS and other functional bowel disorders contain inactive ingredients, which can be dangerous that..., but its most common if youre starting dicyclomine, talk to your doctor, usually 4 times a.! Furosemide ( Lasix ), furosemide ( Lasix ), furosemide ( Lasix ) and. ) in treating IBS and other functional bowel disorders acceptance of eHealthMe.com 's terms of service privacy. Arbs include losartan ( Cozaar ) and with a prescription 2023 by rxlist Inc. An Internet brands.... Intestinal and stomach cramping the symptoms of constipation in people with diverticulitis there are several blood thinners that interact... Bowel disorders diet or commencing or discontinuing any course of treatment rxlist Inc. An Internet brands.... Might experience with IBS and worsen symptoms of constipation in people with diverticulitis, does! Inc. An Internet brands company medications like hyoscyamine also slow down GI motility and may the.